This tool will take you through current, open clinical trials in the UK and help you to understand which trials may be suitable for you. With any clinical trial you will need to be referred by your Health Care Specialist, always seek advice when considering clinical trials.

Further information can be found on our website under Clinical Trials and Novel Drugs or if you would like to speak to someone please call the Myeloma UK infoline on: 0800 980 3332

The Myeloma Trial Finder is intended only to provide information about clinical trials currently available in the UK. Trials included on Myeloma Trial Finder are not necessarily endorsed by Myeloma UK. Clinical trials involve inherent risks and any decision to participate, or not participate, in a clinical trial should be taken only after a careful assessment of the risks involved in it. Please speak to your haematologist if you are interested in taking part in a clinical trial. To the fullest extent permitted by law Myeloma UK excludes all liability howsoever arising (including negligence) as a consequence of, or in connection with, the use of information provided by Myeloma Trial Finder

There are currently 32 open trials. In 132 locations

What is a Clinical Trial?

Step 2: Choose a Trial

There are currently 32 open trials

Step 3: View Details

Trial Title:

Daratumumab in combination with standard myeloma treatment


Daratumumab (Darzalex®)
Bortezomib (Velcade®)
Lenalidomide (Revlimid®)
Melphalan (Alkeran)
Carfilzomib (Kyprolis® )

Myeloma stage:

Relapsed, Refractory, Newly Diagnosed

Trial phase:




This trial is investigating the benefit of  subcutaneous (by injection under the skin)  daratumumab when used in combination with standard myeloma treatments.




Heartlands Hospital, Birmingham;
Royal Bournemouth Hospital, Bournemouth;
Kent and Canterbury Hospital, Canterbury;
Manchester Royal Infirmary, Manchester;
Derriford Hospital, Plymouth;
Royal Stoke University Hospital, Stoke

Who can enter the study?

Who can enter the study?:

Patients who are either newly diagnosed or have relapsed/refractory myeloma.

What's involved?

What's involved?:

Patients will be assigned to one of four treatment regimens.

Newly diagnosed myeloma patients will receive either daratumumab with bortezomib, lenalidomide or dexamethasone (D-VRd) OR daratumumab with bortezomib, melphalan, prednisone and dexamethasone (D-VMP).

Relapsed/refractory myeloma patients will receive either daratumumab with lenalidomide and dexamethasone (D-Rd) OR daratumumab with carfilzomib and dexamethasone (D-Kd).

The study will consist of three phases (screening, treatment and follow-up) and duration of study is approximately 3 years.

Patients are required to attend outpatient clinics for regular check-ups and tests. Tests will  include bone marrow biopsies, blood tests, skeletal surveys and electrocardiograms (EGC).

Clinical Information

Clinical Information
(for Medical Professionals):

This trial will evaluate the clinical benefit of subcutaneous daratumumab  in combination with standard  myeloma treatments.

The trial hopes to demonstrate that the addition of  subcutaneous daratumumab to standard myeloma treatments improves overall response rates or very good partial response (VGPR) compared to data observed in completed phase 3 trials.

For more information, click here.


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