This tool will take you through current, open clinical trials in the UK and help you to understand which trials may be suitable for you. With any clinical trial you will need to be referred by your Health Care Specialist, always seek advice when considering clinical trials.

Further information can be found on our website under Clinical Trials and Novel Drugs or if you would like to speak to someone please call the Myeloma UK infoline on: 0800 980 3332

The Myeloma Trial Finder is intended only to provide information about clinical trials currently available in the UK. Trials included on Myeloma Trial Finder are not necessarily endorsed by Myeloma UK. Clinical trials involve inherent risks and any decision to participate, or not participate, in a clinical trial should be taken only after a careful assessment of the risks involved in it. Please speak to your haematologist if you are interested in taking part in a clinical trial. To the fullest extent permitted by law Myeloma UK excludes all liability howsoever arising (including negligence) as a consequence of, or in connection with, the use of information provided by Myeloma Trial Finder

There are currently 33 open trials. In 125 locations

What is a Clinical Trial?

Step 2: Choose a Trial

There are currently 33 open trials

Step 3: View Details

Trial Title:

Isatuximab in combination with carfilzomib and dexamethasone for relapsed and/or refractory myeloma


Carfilzomib (Kyprolis® )

Myeloma stage:

Relapsed, Refractory

Trial phase:




The aim of this trial is to determine whether the addition of isatuximab to carfilzomib and dexamethasone prolongs progression free survival in relapsed and/or refractory myeloma patients, when compared to treatment with carfilzomib and dexamethasone alone.



Derriford Hospital, Plymouth;
Leicester Royal Infirmary, Leicester

Who can enter the study?

Who can enter the study?:

Relapsed and/or refractory myeloma patients who have received between 1 and 3 prior treatments.

What's involved?

What's involved?:

What’s involved

Patients will be randomised to either received isatuximab, carfilzomib and dexamethasone, or carfilzomib and dexamethasone only.

Isatuximab is given intravenously (into the vein) on days 1, 8, 15 and 22 of the first 28-day cycle, and then on days 1 and 15 for subsequent cycles.

Carfilzomib is given intravenously on days 1, 2, 8, 9, 15 and 16 of each cycle.

Dexamethasone is given either intravenously, or taken by mouth, on days 1, 2, 8, 9, 15, 16, 22 and 23 of the 28-day cycle.

Treatment will continue until there are signs of disease progression. Patients will be required to attend out-patient clinics for regular check-ups and blood tests.

Clinical Information

Clinical Information
(for Medical Professionals):

This is a randomised, open label, Phase III trial to determine the clinical benefit of isatuximab in combination with carfilzomib and dexamethasone in terms of prolonging progression-free survival in relapsed and/or refractory myeloma patients.

For more information, click here

Do you want to talk to someone? Call our myeloma Infoline