The Myeloma Trial Finder lists the clinical trials that are currently recruiting in the UK. If you are thinking about joining a clinical trial you should talk to your healthcare team to find out if this is a suitable option for you.

Further information can be found on our website under Clinical Trials and Novel Drugs or if you would like to speak to someone please call the Myeloma UK infoline on 0800 980 3332

Recruitment to clinical trials may be paused at some hospitals due to the COVID-19 pandemic. Your healthcare team can provide additional details about recruitment to clinical trials in your area.

Last update: 28/09/21

There are currently 28 open trials. In 110 locations

What is a Clinical Trial?

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There are currently 28 open trials

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Trial Title:

Escalating doses of RO7425781 in for relapsed and/or refractory myeloma

Treatments:

RO7425781

Myeloma stage:

Relapsed, Refractory

Trial phase:

I

Summary

Summary:

This trial is investigating whether a drug called RO7425781 is safe and effective for the treatment of relapsed and/or refractory myeloma patients.

RO7425781 is a new type of immunotherapy being tested for the treatment of myeloma. It works by helping your immune cells find and kill myeloma cells.

The trial will consist of two parts.

Part A will consist of patients receiving intravenous infusion or subcutaneous injection of RO7425781 in increasing doses.

Part B will use the results of optimum dosing from part A for a larger group of patients.

 

Locations

Locations:

University College Hospital, London

Who can enter the study?

Who can enter the study?:

Relapsed and/or refractory myeloma patients who have previously received therapy with an immunomodulatory agent, such as lenalidomide (Revlimid®), and a proteasome inhibitor such as bortezomib (Velcade®), and are now intolerant to standard-of-care treatment.

What's involved?

What's involved?:

Patients will be assigned to receive intravenous infusion or subcutaneous injection of RO7425781.

Different groups of patients will be given different doses of the drug.

Patients will be required to attend outpatient clinics for regular check-ups and blood tests. Patients will have to attend follow-up appointments for up to 69 weeks.

Clinical Information

Clinical Information
(for Medical Professionals):

This is a first-in-human, open-label, uncontrolled, multicenter, dose-escalation and expansion Phase I study. The study is
designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-cancer activity of RO7425781 in patients with
relapsed/refractory myeloma, for whom no standard-of-care treatment exists or who are intolerant to those established
therapies.

For more information, click here.

Find

Find out more about Myeloma UK:

Visit www.myeloma.org.uk

Do you want to talk to someone? Call our myeloma Infoline
0800 980 3332